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Published on: January 5, 2016
Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Chiara Balducci1, Laura Pierguidi2,3, Emanuele Persichetti1
1Dipartimento di Medicina Interna, Università degli Studi di Perugia, Perugia, Italy.
Abstract:
Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glucocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.
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