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Updated: Jul 14, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
[Application of autologous platelet-rich gel to refractory chronic diabetic cutaneous ulcers]
1Diabetic Foot Care Center, Department of Endocrinology, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Objective:
To review and evaluate the clinical application of autologous platelet-rich gel (APG) in refractory chronic diabetic cutaneous ulcers.
Methods:
The latest literature was extensively reviewed, and the potential mechanism of APG for healing diabetic cutaneous ulcers was discussed.
Results:
APG accelerated the ulcer healing, especially in healing the refractory diabetic cutaneous ulcers, and the high-level growth factors from the platelet releasate were thought to be the major potential mechanism of the APG action.
Conclusion:
APG can promote the healing of refractory chronic diabetic cutaneous ulcers. Topical haemotherapy with APG may be considered an adjuvant treatment of a multidisciplinary process and may be useful to the effective therapy of cutaneous ulcers.
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