Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetes and the endothelium.

M P Hermans1

  • 1Service d'Endocrinologie & Nutrition, Cliniques universitaires St-Luc, 54, avenue Hippocrate, 1200 Bruxelles, Belgique. michel.hermans@diab.ucl.ac.be

Acta Clinica Belgica
|June 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-invasive screening, staging and management of metabolic dysfunction-associated fatty liver disease (MAFLD) in type 2 diabetes mellitus patients: what do we know so far ?

Acta gastro-enterologica Belgica·2022
Same author

Clinical and biochemical characteristics and analysis of risk factors for euglycaemic diabetic ketoacidosis in type 2 diabetic individuals treated with SGLT2 inhibitors: A review of 72 cases over a 4.5-year period.

Diabetes & metabolic syndrome·2021
Same author

Fully extraperitoneal laparoscopic inguinal hernia repair using conventional mesh versus tailor-made mosquito mesh: a randomized controlled trial from Cameroon.

The British journal of surgery·2021
Same author

Anthropometric and cardiometabolic correlates of prostate volume among diabetic and non-diabetic subjects in South-Kivu.

Diabetes & metabolic syndrome·2019
Same author

Metabolic syndrome components and prostatic hyperplasia among diabetic and non-diabetic men in the Eastern DR Congo: A cross-sectional study.

Diabetes & metabolic syndrome·2019
Same author

Lipoprotein(a) levels are doubled in left-handed patients with diabetes.

Diabetes & metabolism·2018
Same journal

MEFV variants as phenotypic modifiers in ankylosing spondylitis: a genetic interaction analysis with HLA-B27.

Acta clinica Belgica·2026
Same journal

What Europe should (not) learn from the new Dietary Guidelines for Americans.

Acta clinica Belgica·2026
Same journal

Real-world evidence on In-hospital statin use and mortality in geriatric patients.

Acta clinica Belgica·2026
Same journal

TKI-associated proteinuria and nephrotic syndrome: a narrative review with clinical illustration in radio-iodine-refractory thyroid cancer.

Acta clinica Belgica·2026
Same journal

A decade of insulin pump therapy in a Belgian paediatric diabetes centre: longitudinal outcomes and evolving practices.

Acta clinica Belgica·2026
Same journal

Pneumococcal vaccination in Belgian adults: a practical translation of the 2025 Superior Health Council guidelines.

Acta clinica Belgica·2026
See all related articles

High blood sugar in diabetes damages blood vessels by disrupting cellular metabolism. A new theory explains how mitochondrial dysfunction and enzyme inhibition lead to diabetic complications.

Area of Science:

  • Biochemistry
  • Pathophysiology
  • Endocrinology

Background:

  • Abnormal endothelial function is central to diabetic complications.
  • Chronic hyperglycemia causes microvascular and macrovascular damage.
  • Insulin resistance and metabolic syndrome exacerbate endothelial injury in type 2 diabetes.

Purpose of the Study:

  • To present a unifying theory for diabetic endothelial damage.
  • To explain the pathways activated by chronic hyperglycemia.
  • To link metabolic abnormalities to vascular complications.

Main Methods:

  • Review of existing literature on diabetic pathophysiology.
  • Analysis of metabolic pathways involved in hyperglycemia.
  • Integration of molecular mechanisms leading to endothelial dysfunction.

Related Experiment Videos

Main Results:

  • Chronic hyperglycemia triggers metabolic changes via mitochondrial superoxide overproduction.
  • Increased poly(ADP-ribose)polymerase activity inhibits glyceraldehyde-3-phosphate dehydrogenase.
  • This sequence underlies the development of microvascular and macrovascular complications.

Conclusions:

  • A unifying theory explains how hyperglycemia-induced metabolic changes damage endothelial cells.
  • Mitochondrial dysfunction and enzyme inhibition are key pathogenic events.
  • Understanding these pathways is crucial for managing diabetic vascular complications.