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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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Related Experiment Video

Updated: Jul 14, 2026

Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis
10:50

Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis

Published on: November 2, 2018

Advances in malaria diagnosis.

Michael Hawkes1, Kevin C Kain

  • 1Pediatric Infectious Diseases, University of Toronto, MaRS Centre, Toronto Medical Discovery Tower, Toronto, Ontario, Canada. michael.hawkes@utoronto.ca

Expert Review of Anti-Infective Therapy
|June 6, 2007
PubMed
Summary

Accurate malaria diagnostic tests can save lives. New technologies like immunochromatographic tests and PCR offer improved field and lab diagnostics, overcoming limitations of traditional microscopy.

Area of Science:

  • Medical diagnostics
  • Parasitology
  • Public health

Background:

  • Malaria remains a major global cause of death, with accurate diagnosis crucial for saving lives.
  • Traditional light microscopy for malaria diagnosis is labor-intensive and requires specialized expertise.
  • Overtreatment of malaria is a significant issue in resource-poor endemic areas.

Purpose of the Study:

  • To review emerging diagnostic technologies for malaria.
  • To highlight the potential of new methods to overcome limitations of light microscopy.
  • To discuss the applicability of novel diagnostics in different settings.

Main Methods:

  • Review of current and experimental malaria diagnostic technologies.
  • Comparison of new methods with traditional light microscopy.

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Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis
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  • Assessment of ease of use, cost, sensitivity, and specificity.

    • Main Results:

    • Immunochromatographic tests offer inexpensive and easy-to-use field diagnostics, aiding in reducing overtreatment.
    • Polymerase chain reaction (PCR) assays provide high sensitivity and species identification, suitable for developed countries.
    • Flow cytometry and mass spectrometry are being explored for high-throughput screening.

    Conclusions:

    • New malaria diagnostic technologies offer significant advantages over traditional methods.
    • Field-deployable tests and sensitive laboratory assays are improving malaria case management.
    • Advancements in diagnostics hold promise for reducing malaria mortality and improving treatment efficacy.