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Updated: Jul 14, 2026
Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine
Published on: October 27, 2023
Effect of chronic stress and L-carnitine on rat stomach
V Nimet Izgüt-Uysal1, Mehmet Bülbül, Ruken Tan
1Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey. nimetu@akdeniz.edu.tr
Background And Aim:
L-Carnitine is an essential cofactor in the mitochondrial transfer of fatty acids, and it is also a scavenger of free radicals in mammalian tissues. The aim of the study was to determine the effect of L-carnitine on chronic restraint stress-induced gastric mucosal injury.
Methods:
Wistar rats were applied restraint stress (1 h/day) and L-carnitine (50 mg/kg) for 21 days. The lesion index, prostaglandin E(2) and mucus content, lipid peroxidation, superoxide dismutase, and catalase activity in gastric mucosa were evaluated.
Results:
Chronic restraint stress increased the lesion index, lipid peroxidation, and superoxide dismutase activity in gastric mucosa, and it decreased prostaglandin E(2) and mucus content. L-Carnitine treatment prevented the stress-induced increase in lesion index, lipid peroxidation and a stress-induced decline in prostaglandin E(2), and mucus content in gastric mucosa, but it increased catalase activity.
Conclusions:
L-Carnitine prevents the occurrence of lesion by strengthening the gastric mucosal barrier and by reducing lipid peroxidation against the harmful effects of chronic restraint stress.