[The reference values of glycemic parameters for continuous glucose monitoring and its clinical application]

To establish reference values of glycemic parameters for continuous glucose monitoring in Chinese.

Forty-eight individuals with normal glucose regulation were observed with continuous glucose monitoring system (CGMS) for 3 days. Indexes in CGMS were analyzed, including mean level of 24 h blood glucose (BG) values (24 h MBG) and its standard deviation (SDBG), percentage of time above 7.8 mmol/L or below 3.9 mmol/L, area under the curve (AUC) of BG above 5.6 mmol/L, the largest amplitude of glycemic excursions (LAGE), mean amplitude of glycemic excursions (MAGE) and absolute means of daily differences (MODD).

(1) The upper limits of indexes for continuous glucose monitoring were as follows: 6.5 mmol/L for 24 h MBG, 6.0 mmol/L, 6.3 mmol/L and 6.0 mmol/L for mean BG levels 1 h before breakfast, lunch and dinner respectively, 7.0 mmol/L, 6.7 mmol/L and 7.0 mmol/L for mean BG levels 3 h after breakfast, lunch and dinner respectively, 1.4 mmol/L for SDBG, 5.7 mmol/L for LAGE, 3.4 mmol/L for MAGE and 1.4 mmol/L for MODD. The percentage of time over 7.8 mmol/L was less than 9%, while the percentage of time below 3.9 mmol/L was less than 20%. The AUC of BG above 5.6 mmol/L was less than 0.9 d x mmol x L(-1). There was no statistical difference among sex subgroups (P > 0.05). (2) The correlations of 24h MBG with MAGE, MODD and SDBG were not significant (P > 0.05). MAGE was positively correlated with SDBG (r = 0.93, P < 0.01).

The reference values of glycemic parameters for continuous glucose monitoring are initially established and can be used as a temporary reference for clinical practice in Chinese. The CGMS profile can reflect the overall BG control and the feature of glycemic excursions in detail.