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Updated: Jul 14, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
The effects of fine-needle biopsy on thyroid hormone levels
H Cengiz Alpay1, Turgut Kalidag, Erol Keles
1Firat University Medical Faculty, Otorhinolaryngology Department, Elaziğ, Turkey. hayrettincengizalpay@yahoo.com
Objective:
Our study aim was to investigate the effects of fine-needle biopsy used for thyroid nodules on serum thyroid hormone levels.
Study Design:
A total of 25 patients who had solid nodules of the thyroid gland and normal thyroid hormone levels underwent diagnostic fine-needle biopsy for a nodule of the thyroid gland.
Methods:
Venous blood samples were drawn from the cases for measurement of serum total T(3) and T(4), free T(3) and T(4), thyroid-stimulating hormone, and thyroglobulin levels before, immediately after, and 30 minutes after the initial biopsy.
Results:
Total T(3) and thyroglobulin levels were found to be significantly higher immediately and 30 minutes following fine-needle aspiration biopsy, compared to the baseline levels (P<0.05).
Conclusion:
Preliminary data suggest that thyroid hormone levels show a mean increase of about 20% immediately after fine-needle aspiration.
Significance:
The implication of this finding on patient care should be determined on an individual basis.
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