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Published on: July 20, 2022
Development of a computer-aided diagnosis system for continuous peritoneal dialysis: an availability of the
Hiroyuki Hamada1, Shinji Namoto, Ryo Yamada
1Laboratory for Bioinformatics, Graduate School of Systems Life Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. hamada@brs.kyushu-u.ac.jp
Abstract:
We developed a novel diagnostic system for continuous peritoneal dialysis, which evaluates the peritoneal permeability and hydraulic conductance (peritoneal function) by applying the kinetic model and a clinical test with minimum nursing time. Kinetic parameters for the peritoneal function were determined by the simultaneous numerical optimization techniques (SNOT). Furthermore dialysis outcome and ultrafiltration volume were estimated and predicted by using the kinetic model with a set of optimal kinetic parameters, which were in agreement with measured data (r(2)>0.82). The clinical implementation of the SNOT is very useful to explore the better prescriptions for each patient's clinical condition.
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