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Published on: February 7, 2018
Gender-related differences in oxidative stress levels among elderly patients with coronary artery disease
Cristina Vassalle1, Silvia Maffei, Claudio Boni
1CNR Institute of Clinical Physiology, Pisa, Italy. cristina.vassalle@ifc.cnr.it
Objective:
To evaluate whether gender-related differences exist concerning oxidative stress levels in aged patients with coronary artery disease (CAD).
Design:
Case-control.
Setting:
Clinical and research center.
Patient(S):
Elderly subjects of both genders with or without CAD.
Intervention(S):
None.
Main Outcome Measure(S):
Serum hydroperoxides (HP) as index of oxidative stress levels.
Result(S):
The HP levels were comparable in aged control subjects of both genders (376 +/- 20 arbitrary units [AU] in women, 333 +/- 19 AU in men) but significantly increased in CAD (456 +/- 15 AU) compared with all control subjects (357 +/- 14 AU). Moreover, among CAD patients, the HP levels were higher in women than in men (536 +/- 33 AU and 428 +/- 15 AU, respectively). Multivariate analysis, in which CAD represented the dependent variable, indicated that dyslipidemia was independently associated with CAD in men (odds ratio [OR] 5.8), whereas HP >50th percentile represented the only strong independent risk factor for CAD in elderly women (OR 8.4).
Conclusion(S):
Differences in oxidative stress levels between elderly males and females might provide a biochemical basis for the epidemiologic differences in CAD, which might help to open new opportunities in the management of patients with cardiovascular disease from a gender point of view.
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