Related Experiment Video
Updated: Jul 14, 2026

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major
Published on: October 28, 2022
Leishmania MAP kinases--familiar proteins in an unusual context
1Bernhard Nocht Institute for Tropical Medicine, Parasitology Section, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany. martin.wiese@bni-hamburg.de
Abstract:
Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.
Related Concept Videos
Leishmaniasis
Antiprotozoal Agents
MAPK Signaling Cascades
Microtubule Associated Proteins (MAPs)
cAMP-dependent Protein Kinase Pathways

