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Related Experiment Video

Updated: Jul 14, 2026

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma
08:25

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Published on: April 25, 2025

Specific molecular markers in hepatocellular carcinoma.

Deng-Fu Yao1, Zhi-Zhen Dong, Min Yao

  • 1Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, Nantong 226001, China. Yaodf@ahnmc.com

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|June 6, 2007
PubMed
Summary

Early diagnosis and monitoring of hepatocellular carcinoma (HCC) is crucial. Specific circulating biomarkers, including alpha-fetoprotein (AFP) subfractions and genetic markers, show promise for detecting HCC and its recurrence.

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Hepatocellular Carcinoma Research

Background:

  • Hepatocellular carcinoma (HCC) development is complex with poor prognosis.
  • Early diagnosis and metastasis monitoring are critical for patient outcomes.
  • Circulating biomarkers offer potential for early detection and postoperative management.

Purpose of the Study:

  • To review recent studies on specific biomarkers for HCC diagnosis.
  • To evaluate biomarkers for monitoring HCC metastasis and postoperative recurrence.

Main Methods:

  • Literature search of MEDLINE (June 1998 - September 2006).
  • Focus on specific biomarkers for HCC diagnosis and metastasis monitoring.

Main Results:

  • Hepatoma tissues secrete tumor-related markers into circulation.
  • Specific biomarkers like AFP subfraction, TGF-beta1, HS-GGT, and IGF-II show higher specificity for early HCC diagnosis than total AFP.
  • Circulating genetic markers (AFP-mRNA, TGF-beta1-mRNA, IGF-II-mRNA) are effective for monitoring metastasis and recurrence.

Conclusions:

  • Analysis of circulating hepatoma-specific biomarkers aids in early HCC diagnosis.
  • These biomarkers are valuable for monitoring metastasis and postoperative recurrence of HCC.