[Research progress on nonsyndromic X-linked mental retardation related gene PAK3]
Xiao-Cai Gao1, Geng-Si Xi, Fu-Chang Zhang
1College of Life Science, Shaanxi Normal University, Xi'an 710062, China. gaoxc@nwu.edu.cn
Yi Chuan = Hereditas
|June 6, 2007
Abstract:
Mutations of the gene coding for PAK3 (p21-activated kinase 3) are associated with nonsyndromic X-linked mental retardation (MRX). It may be associated with generalized or specific cognitive ability. Studying the biological and cognitive function of PAK3 is important for MR diagnosis and prevention. This paper reviews the progress on PAK3 including its gene product, biological and cognitive function. The future directions on the study of PAK3 are also discussed.
