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Related Experiment Videos

CCR4-dependent regulatory T cell function in inflammatory bowel disease.

Qian Yuan1, Shannon K Bromley, Terry K Means

  • 1Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

The Journal of Experimental Medicine
|June 6, 2007
PubMed
Summary
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Regulatory T (T reg) cells prevent inflammatory bowel disease (IBD) colitis. CCR4 is crucial for T reg cell trafficking to lymph nodes, enabling their function in preventing colitis development.

Area of Science:

  • Immunology
  • Gastroenterology

Background:

  • Inflammatory bowel disease (IBD) involves complex immune dysregulation in the intestine.
  • CD4(+) T lymphocytes, particularly regulatory T (T reg) cells, are key in modulating intestinal inflammation.
  • The exact mechanisms of T reg cell-mediated colitis prevention and the role of chemokine receptors remain incompletely understood.

Purpose of the Study:

  • To investigate the role of the chemokine receptor CCR4 in the in vivo trafficking and suppressive function of T reg cells in a mouse model of IBD.
  • To determine if CCR4 is essential for T reg cell accumulation in mesenteric lymph nodes (MLNs) and subsequent colitis suppression.

Main Methods:

  • Utilized a mouse adoptive transfer model of IBD.
  • Compared the effects of wild-type T reg cells versus CCR4-deficient T reg cells on colitis development.

Related Experiment Videos

  • Analyzed T reg cell accumulation in MLNs at different time points post-transfer.

    • Main Results:

    • CCR4-deficient T reg cells showed impaired accumulation in MLNs at early time points (2-5 days) after adoptive transfer.
    • This early failure in trafficking led to an inability to suppress pathogenic T cell generation and prevent colitis.
    • While CCR4-deficient T reg cells retained in vitro suppressive capacity and showed later MLN accumulation, they failed to suppress established colitis.

    Conclusions:

    • CCR4 plays a critical role in the early in vivo trafficking of T reg cells to mesenteric lymph nodes.
    • This CCR4-mediated trafficking is essential for the suppressive function of T reg cells in preventing the development of colitis in this IBD model.