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Tobacco smoke exposure is associated with attenuated endothelial function in 11-year-old healthy children

Katariina Kallio1, Eero Jokinen, Olli T Raitakari

  • 1Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland. katariina.kallio@utu.fi

Circulation
|June 6, 2007
PubMed

Insights

Passive smoking, measured by serum cotinine, harms endothelial function in children. This study shows a dose-dependent impairment of blood vessel dilation in 11-year-olds exposed to environmental tobacco smoke.

Area of Science:

  • Pediatric cardiology
  • Environmental health
  • Vascular biology

Background:

  • Passive smoking is linked to arterial damage in adults.
  • Its impact on children's endothelial function remains unclear.

Purpose of the Study:

  • To investigate the effect of passive smoking on endothelial function in children.
  • To determine if cotinine levels correlate with vascular health in pediatric subjects.

Main Methods:

  • Longitudinal study of children (8-11 years) in a prospective atherosclerosis prevention trial.
  • Serum cotinine levels measured annually.
  • Endothelium-dependent flow-mediated dilation of the brachial artery assessed via ultrasound at age 11.

Main Results:

  • Increased serum cotinine concentration was associated with reduced flow-mediated dilation in 11-year-old children.
  • A dose-dependent relationship was observed between cotinine levels and impaired endothelial function.
  • These associations persisted even after accounting for traditional risk factors.

Conclusions:

  • Environmental tobacco smoke exposure, verified by cotinine levels, negatively impacts endothelial function in children.
  • The findings indicate a dose-dependent impairment of vascular health in children exposed to passive smoke.
Abstract

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