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Updated: Jul 14, 2026

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

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Paget-Schroetter syndrome.

Gursel L Oktar¹, Emin G Ergul

¹Division of Cardiovascular Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey. loktar@isnet.net.tr

Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi

|June 6, 2007

Summary

Paget-Schroetter syndrome, or effort thrombosis, is a rare deep vein thrombosis caused by strenuous arm activity. Early diagnosis and appropriate management are crucial to prevent long-term disability from post-thrombotic syndrome.

Area of Science:

Vascular Surgery
Thrombosis Research
Sports Medicine

Background:

Paget-Schroetter syndrome (PSS), also known as effort thrombosis, is an uncommon deep vein thrombosis (DVT) affecting the axillary-subclavian veins.
It typically results from repetitive strenuous upper extremity activity, leading to venous compression and thrombus formation.
Untreated PSS can progress to debilitating post-thrombotic syndrome (PTS).

Observation:

This report details a case of PSS in a young male weightlifter, a demographic susceptible to exertional venous injuries.
The patient's presentation highlights the clinical manifestations of PSS in an athletic individual.
The case underscores the importance of considering PSS in young, active individuals presenting with upper extremity swelling and pain.

Findings:

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The optimal management for PSS remains debated due to limited evidence from small studies.
Treatment strategies discussed include anticoagulation, thrombolysis, and surgical decompression, with varying success rates.
This case illustrates the diagnostic and therapeutic challenges associated with PSS.

Implications:

Prompt diagnosis and tailored treatment are essential to mitigate the risk of PTS and long-term arm dysfunction.
Further research with larger cohorts is needed to establish evidence-based guidelines for PSS management.
This case contributes to the understanding of PSS in athletes and informs clinical decision-making.