Related Experiment Video
Updated: Jul 14, 2026
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Elution behavior of daptomycin-loaded calcium sulfate pellets: a preliminary study
Kelly C Richelsoph1, Nathan D Webb, Warren O Haggard
1Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152-3210, USA.
Clinical Orthopaedics and Related Research
|June 6, 2007
Summary
Daptomycin can be effectively incorporated into calcium sulfate pellets for localized delivery in musculoskeletal infections. This study details the elution profile and dissolution rates, confirming its suitability as a therapeutic agent.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Pharmacology
Background:
- Daptomycin is effective against resistant Gram-positive bacteria.
- Calcium sulfate is a resorbable bone graft substitute suitable for local drug delivery.
Purpose of the Study:
- To evaluate the elution characteristics and dissolution rates of daptomycin in calcium sulfate pellets.
- To compare daptomycin elution with tobramycin in the same matrix.
Main Methods:
- Calcium sulfate pellets were prepared with daptomycin or tobramycin.
- Antibiotic elution was measured over 28 days.
- In vitro dissolution rates of pellets were determined.
Main Results:
- Daptomycin elution was high initially (537 microg/mL/g on day 1) and decreased over time.
- Elution profiles differed from tobramycin in the first three days but were similar thereafter.
- Daptomycin pellets showed faster in vitro dissolution than tobramycin pellets.
Conclusions:
- Special techniques are required to incorporate daptomycin into calcium sulfate hemihydrate.
- Daptomycin can be successfully incorporated into calcium sulfate for local delivery.
- The elution profile suggests potential for treating severe musculoskeletal infections.
