Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The nuclear envelope and transcriptional control.

Asifa Akhtar1, Susan M Gasser

  • 1EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Akhtar@embl.de

Nature Reviews. Genetics
|June 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HPL-2/HP1 and MET-2/SETDB1 bind distinct co-factors that promote heterochromatic foci, gene repression and organogenesis independently of H3K9 methylation.

bioRxiv : the preprint server for biology·2026
Same author

H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions.

Cell reports·2026
Same author

Histone acetylation-dependent clustering of BRD2 instructs transcription dynamics.

Nature genetics·2026
Same author

Stage-specific epigenetic priming amplifies gene activation during lineage commitment.

Science advances·2026
Same author

Nucleoli-localized KANSL2 as an epigenetic regulator of ribosome biogenesis in glioblastoma cells.

Communications biology·2026
Same author

The Double Face of Base Excision Repair: Preventing and Triggering Double-Strand Breaks.

BioEssays : news and reviews in molecular, cellular and developmental biology·2025

Gene activity is regulated by nuclear positioning and nuclear envelope components. Active genes are found at nuclear pores, suggesting a role in heritable gene expression regulation.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cells utilize multi-protein complexes to regulate gene transcription.
  • Nuclear positioning is increasingly recognized as a key factor in controlling gene expression.
  • Nuclear envelope components play a central role in this regulation.

Purpose of the Study:

  • To investigate the role of nuclear positioning and nuclear envelope components in gene expression.
  • To understand how active and silent chromatin are localized within the nucleus.
  • To explore the regulatory function of nuclear-pore structures in gene expression.

Main Methods:

  • Analysis of gene localization within the nucleus.
  • Examination of nuclear envelope components and their association with chromatin.

Related Experiment Videos

  • Investigation of RNA-processing and export machinery recruitment.

    • Main Results:

    • Active genes are found to localize to nuclear-pore structures on the inner nuclear envelope.
    • Silent chromatin localizes to non-pore sites within the nucleus.
    • Nuclear-pore components are involved in recruiting RNA-processing and export machinery.

    Conclusions:

    • Nuclear positioning, particularly at nuclear pores, is crucial for regulating gene activity.
    • Nuclear-pore structures may provide a mechanism for heritable gene expression regulation.
    • These findings highlight a novel layer of gene expression control mediated by the nuclear envelope.