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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
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Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
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Related Experiment Video

Updated: Jul 14, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Fibromyalgia: revisiting the literature.

Diane Forbes1, Andrew Chalmers

  • 1bots@telus.net

The Journal of the Canadian Chiropractic Association
|June 6, 2007
PubMed
Summary

Fibromyalgia, characterized by chronic pain and tender points, lacks a clear pathological basis. While treatments help coping, they don't eliminate symptoms, and prognosis varies.

Area of Science:

  • Rheumatology
  • Pain Medicine
  • Clinical Immunology

Background:

  • Fibromyalgia presents with widespread chronic pain and specific tender points.
  • The American College of Rheumatology (ACR) criteria identify tender points but lack empirical pathological links.
  • Fibromyalgia may coexist with psychological conditions, but its etiology remains unclear.

Purpose of the Study:

  • To review the clinical presentation and diagnostic criteria for fibromyalgia.
  • To examine the empirical evidence supporting the link between tender points and pathological processes.
  • To assess the measurement of outcomes and prognosis in fibromyalgia patients.

Main Methods:

  • Literature review of studies utilizing ACR criteria for fibromyalgia diagnosis.

Related Experiment Videos

Last Updated: Jul 14, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

  • Analysis of research on the association between tender points and underlying pathology.
  • Evaluation of outcome measurement tools and prognostic factors in fibromyalgia care.
  • Main Results:

    • No solid empirical evidence links the 11 or more tender points to a specific pathological process.
    • Tender points may be a concomitant finding in psychological disease states, not offering etiological insight.
    • Outcome measurement in fibromyalgia is challenging, with poor prognosis in specialty care but variable outcomes in the general population, including spontaneous improvement.

    Conclusions:

    • Fibromyalgia's distinct presentation, marked by chronic pain and tender points, lacks a defined pathological basis.
    • Current treatments primarily aid in coping with fibromyalgia symptoms rather than eliminating them.
    • Prognosis for fibromyalgia varies, with some patients improving without specific interventions.