Perspectives for preventive screening with total body MRI

Radiology has started to increasingly recognise its potential for screening with the advent of "whole-body" imaging techniques. This article briefly reviews prerequisites for successful screening, presents a quick summary of single-organ screening with magnetic resonance (MR) imaging, and introduces how this knowledge can be integrated into whole-body MR (wb-MR) screening. MR colonography has demonstrated its potential for screening. Wb-MR in the form of wb-MR angiography has already entered both clinical and screening settings; also, the search for metastases with wb-MR has been evaluated and has performed well when compared with other imaging modalities. But screening a group of healthy subjects requires more than feasibility and high accuracy of the screening test; thus, technical and ethical considerations are also presented. Wb-MR is only at its beginning and will in the near future certainly inspire many new research activities as well as transform the radiological market.