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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
[Side effects of fibrates (except liver and muscle)]
1Centre Régional de Pharmacovigilance de Bourgogne, CHU de Dijon, UER de Médecine.
Therapie
|September 1, 1991
Summary
Fibrate therapy, excluding muscle and liver issues, shows low toxicity. Most common side effects are skin reactions and blood disturbances, with good recovery rates.
Area of Science:
- Pharmacovigilance
- Drug Safety
- Clinical Pharmacology
Context:
- Fibrates are hypolipidemic drugs with known muscle and liver side effects.
- Other adverse effects of fibrates are less understood.
- This study investigates non-muscular and non-hepatic side effects of fibrates.
Purpose:
- To analyze pathological events associated with fibrate therapy.
- To identify and quantify less-known adverse effects of fibrates.
- To assess the safety profile of fibrates beyond rhabdomyolysis and hepatic diseases.
Summary:
- A 5-year analysis (1985-1989) of 277 fibrate-related side effects (excluding muscle/liver) from French pharmacovigilance data.
- Commonly reported side effects included skin reactions (22.8%), blood disturbances (9.8%), and gastrointestinal/nervous system disorders (approx. 6% each).
- Drug interactions, particularly with coumarin derivatives, accounted for clotting disturbances (5.8%).
Impact:
- Fibrates exhibit a generally low toxicity profile for non-muscular and non-hepatic adverse events.
- Skin reactions and drug interactions are the most frequent side effects.
- The majority of cases showed good recovery (80.9%) with no fatalities, suggesting a favorable safety margin for fibrates.
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