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[Agranulocytosis under metapramine. A "well-known" effect without bibliographical data]
G Vernet1, O Oules, H Poinas-Caillaud
1Service de Pneumologie, Centre Hospitalier Emile Roux, Le Puy-en-Velay.
Therapie
|September 1, 1991
Summary
Metapramine, a tricyclic antidepressant, can cause agranulocytosis, a rare but serious blood disorder. This case report confirms a causal link between metapramine and agranulocytosis in an elderly patient.
Area of Science:
- Pharmacology
- Hematology
Background:
- Metapramine (Timaxel) is a tricyclic antidepressant.
- It lacks anticholinergic properties but may cause hyperthermia.
- Agranulocytosis is a rare adverse effect associated with psychotropic drugs.
Observation:
- A case of an elderly woman experiencing two episodes of fever and asthenia.
- Blood tests revealed agranulocytosis without anemia or thrombocytopenia during both episodes.
- Accidental rechallenge with metapramine was performed.
Findings:
- The rechallenge confirmed a causal relationship between metapramine intake and agranulocytosis.
- This is the first reported publication of metapramine-induced agranulocytosis, despite previous reports to pharmacovigilance.
Implications:
- Highlights the potential for metapramine to cause severe hematological adverse effects.
- Emphasizes the importance of monitoring blood counts in patients taking metapramine.
- Contributes to the understanding of rare drug side effects and pharmacovigilance data.