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Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
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Published on: June 8, 2019

Clinical laboratory reports in molecular pathology.

Margaret L Gulley1, Rita M Braziel, Kevin C Halling

  • 1Department of Pathology, 913 Brinkhous-Bullitt Bldg, University of North Carolina, Chapel Hill, NC 27599-7525, USA. margaret_gulley@med.unc.edu

Archives of Pathology & Laboratory Medicine
|June 7, 2007
PubMed
Summary

Standardizing molecular pathology reports is crucial as DNA and RNA testing becomes more common. This ensures clear communication of complex genetic test results for better patient care.

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Area of Science:

  • Molecular pathology
  • Laboratory medicine
  • Genomic analysis

Background:

  • Molecular pathology, analyzing DNA and RNA, is expanding in laboratory medicine.
  • Array technology enables massive parallel analysis of multiple genes, transcripts, and proteins, increasing complexity.

Framework:

  • Summarizing common elements in molecular pathology reports based on existing accreditation checklists.
  • Proposing consensus recommendations for improving report format and content.
  • Discussing areas of controversy in molecular pathology reporting.

Implementation:

  • Utilizing resources for proper gene nomenclature.
  • Describing standardized methods for reporting various genetic alterations.
  • Addressing reporting for inherited diseases, cancer, identity testing, microbiology, and pharmacogenetics.

Implications:

  • Providing a framework for molecular pathology reports.
  • Ensuring clear communication of molecular test results and clinical significance.
  • Facilitating effective collaboration among healthcare teams.