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Related Experiment Video

Updated: Jul 14, 2026

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Hyperhomocysteinemia and thrombosis: an overview.

Mohamed M Eldibany¹, Joseph A Caprini

¹Department of Pathology and Laboratory Medicine, Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA. meldibany@enh.org

Archives of Pathology & Laboratory Medicine

|June 7, 2007

Summary

High homocysteine levels (hyperhomocysteinemia) are linked to vascular disease. While severe cases show links to atherosclerosis, the impact of mild hyperhomocysteinemia and its genetic causes on thrombosis remains debated.

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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

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Last Updated: Jul 14, 2026

Ferric Chloride-induced Murine Thrombosis Models

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Published on: September 5, 2016

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Area of Science:

Biochemistry
Genetics
Vascular Medicine

Background:

Homocysteine is a key metabolic intermediary in transmethylation and transsulfuration.
Essential reactions involving homocysteine support cellular growth, differentiation, and function.
Elevated homocysteine levels (hyperhomocysteinemia) are implicated in vascular diseases.

Purpose of the Study:

To review homocysteine metabolism and hyperhomocysteinemia.
To examine the link between homocysteine, MTHFR defects, and thromboembolism.
To assess the role of vitamin supplementation in managing hyperhomocysteinemia.

Main Methods:

Comprehensive review of published medical and scientific literature.
Selection and critical appraisal of articles relevant to the study objectives.
Synthesis and comparison of findings from pertinent studies.

Main Results:

The association between hyperhomocysteinemia and thrombosis is controversial.
Severe hyperhomocysteinemia is linked to atherosclerosis.
The role of mild hyperhomocysteinemia in thrombosis is less certain.

Conclusions:

Coinheritance of MTHFR defects and Factor V Leiden increases venous thromboembolism risk.
The link between MTHFR defects alone and venous thrombosis is unclear.
High-dose folic acid for lowering homocysteine may not always be necessary.