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Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

Sara Fröjdö1, Delphine Cozzone, Hubert Vidal

  • 1Inserm U-870, INRA U-1235, INSA/UCBL/HCL, Laennec Medical Faculty, Claude Bernard-University Lyon 1, Lyon, France.

The Biochemical Journal
|June 7, 2007
PubMed

Insights

Resveratrol, a fruit polyphenol, activates sirtuins and inhibits phosphoinositide 3-kinase (PI3K). This dual action may explain its cancer-fighting and longevity-promoting effects.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Gerontology

Background:

  • Resveratrol, a polyphenol from fruits, exhibits anticancer and life-extending properties.
  • Sirtuins (e.g., SIRT1) and phosphoinositide 3-kinase (PI3K) pathways are implicated in aging and cancer.
  • Targeting these pathways is a strategy for cancer therapy and longevity.

Purpose of the Study:

  • To investigate the molecular targets of resveratrol.
  • To determine if resveratrol affects PI3K signaling.
  • To link resveratrol's effects on sirtuins and PI3K to its health benefits.

Main Methods:

  • In vitro enzymatic assays.
  • Cellular studies using cultured muscle cells.
  • Analysis of downstream signaling pathways.

Main Results:

  • Resveratrol activates sirtuins at specific concentrations.
  • Resveratrol inhibits class IA PI3K and its downstream signaling.
  • These effects occur within a similar concentration range.

Conclusions:

  • Class IA PI3K is a novel molecular target of resveratrol.
  • Resveratrol's inhibition of PI3K contributes to its anticancer and longevity effects.
  • Resveratrol is identified as a natural, class-specific inhibitor of PI3K.

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