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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Relationship between low bone mineral density and exercise-induced myocardial ischemia
Aaron M From1, Joseph A Hyder, Ann M Kearns
1Department of Internal Medicine, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Mayo Clinic Proceedings
|June 7, 2007
Summary
Lower bone mineral density (BMD) is linked to reduced exercise capacity and increased risk of myocardial ischemia. Individuals with low BMD showing cardiovascular symptoms face a higher likelihood of ischemia.
Area of Science:
- Cardiology
- Endocrinology
- Geriatrics
Background:
- Bone mineral density (BMD) is a key indicator of skeletal health.
- Cardiovascular disease remains a leading cause of morbidity and mortality.
- The relationship between BMD, ischemic heart disease, and exercise capacity requires further elucidation.
Purpose of the Study:
- To investigate the association between femoral neck bone mineral density (BMD) and exercise capacity.
- To evaluate the correlation between BMD and the incidence of ischemic heart disease.
- To assess the impact of low BMD on myocardial ischemia risk during stress testing.
Main Methods:
- Retrospective analysis of 1142 patients undergoing exercise echocardiography.
- Measurement of femoral neck BMD using dual-energy x-ray absorptiometry.
- Assessment of exercise capacity via Bruce protocol stress testing.
Main Results:
- A decrease in femoral neck T score correlated with reduced exercise duration (0.23 minutes per unit decrease).
- Each unit decrease in T score was associated with a 22% increased risk of myocardial ischemia.
- Patients with low BMD (T score ≤ -1.0) had a 43% higher risk of myocardial ischemia.
Conclusions:
- Reduced bone mineral density is significantly associated with diminished exercise capacity.
- Lower BMD is a predictor of myocardial ischemia in patients undergoing stress testing.
- Individuals with low BMD presenting with cardiovascular symptoms have a greater likelihood of experiencing myocardial ischemia.
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