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Mate Choice01:20

Mate Choice

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Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
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The Ratio of X Chromosome to Autosomes02:45

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In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
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Background and Environment Affect Phenotype02:27

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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Dosage Compensation02:50

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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with  distinct numbers of X chromosomes will...
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The Y Chromosome Determines Maleness02:19

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The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
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Development of the Sexual Organs in the Embryo and Fetus01:15

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Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
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Related Experiment Video

Updated: Jan 19, 2026

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi
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Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

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Systems biology: a switch for sex.

Steven S Andrews1, Adam P Arkin

  • 1Physical Biosciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, M.S. 977-152, Berkeley, California 94720, USA. ssandrews@lbl.gov <ssandrews@lbl.gov>

Current Biology : CB
|June 7, 2007
PubMed
Summary
This summary is machine-generated.

Researchers modified the yeast pheromone response pathway, a system typically showing a graded response, into a bistable switch. This finding has significant implications for understanding the evolution and engineering of biological reaction networks.

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Related Experiment Videos

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Area of Science:

  • Cellular biology
  • Systems biology
  • Biochemistry

Background:

  • The yeast pheromone response pathway is a well-studied signaling cascade.
  • This pathway typically exhibits a graded response, meaning the output intensity correlates directly with the input pheromone concentration.

Purpose of the Study:

  • To investigate the potential for modifying the yeast pheromone response pathway.
  • To explore the conversion of a graded response system into a bistable switch.

Main Methods:

  • Utilized genetic and molecular biology techniques to introduce specific modifications to the yeast pheromone response pathway.
  • Analyzed the pathway's behavior under varying pheromone concentrations to assess response dynamics.

Main Results:

  • Demonstrated that small, targeted modifications can fundamentally alter the pathway's response characteristics.
  • Successfully converted the graded pheromone response into a bistable switch, exhibiting distinct "on" and "off" states.

Conclusions:

  • The yeast pheromone response pathway is amenable to engineering for altered functionality.
  • Bistable switches can be derived from graded response systems, offering insights into network evolution and design.