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Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Related Experiment Video

Updated: Jul 14, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
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Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

Published on: May 6, 2009

Live longer through PHAsting.

Arjan B Brenkman1, Boudewijn M T Burgering

  • 1Laboratory of Physiological Chemistry, Division of Biomedical Genetics, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. a.b.brenkman@umcutrecht.nl

Cell Metabolism
|June 7, 2007
PubMed
Summary

Dietary restriction extends lifespan. Researchers found PHA-4/FoxA is crucial for this effect in C. elegans, highlighting its role in longevity.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Genetics

Background:

  • Dietary restriction (DR) is known to confer significant health benefits, including increased lifespan in various organisms.
  • Understanding the molecular mechanisms underlying DR-induced longevity is a key area of aging research.

Discussion:

  • This study identifies PHA-4/FoxA as a specific and essential factor in the lifespan-extending effects of dietary restriction in the model organism C. elegans.
  • The findings suggest a conserved role for PHA-4/FoxA in mediating the benefits of reduced caloric intake on longevity.

Key Insights:

  • PHA-4/FoxA is a critical molecular component driving lifespan extension under dietary restriction.
  • The identification of PHA-4/FoxA provides a new target for understanding and potentially manipulating aging processes.

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Last Updated: Jul 14, 2026

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells
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08:53

High-Throughput Behavioral Aging and Lifespan Assays Using the Lifespan Machine

Published on: January 26, 2024

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10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

Outlook:

  • Further research can explore the downstream targets and regulatory pathways of PHA-4/FoxA in response to dietary restriction.
  • Investigating the conservation of PHA-4/FoxA's role in lifespan extension across different species could offer insights into human aging.