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Immune-mediated hemolysis associated with the administration of a radiographic contrast medium
R Nordhagen1, H Vik, K Wolthuis
1Department of Immunology, National Institute of Public Health, Oslo, Norway.
Transfusion
|November 1, 1991
Abstract:
A female patient developed serious hemolysis in association with the injection of a radiographic contrast medium (RCM). Serologic investigation of her serum suggested complement-mediated hemolysis, induced by an RCM-dependent IgM antibody in her serum. The antibody was of high titer and low avidity. The antibody showed cross-reactions with related radiographic contrast media and reacted only with group I adult RBCs.