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Maternal smoking habits and cognitive development of children at age 4 years in a population-based birth cohort
Jordi Julvez1, Núria Ribas-Fitó, Maties Torrent
1Centre for Research in Environmental Epidemiology, Institut Municipal d'Investigació Mèdica. Barcelona, Spain. jjulvez@imim.es
Insights
Maternal smoking during pregnancy is linked to lower cognitive development in children by age 4. This study highlights the impact of prenatal smoke exposure on preschooler cognitive abilities and executive functions.
Area of Science:
- Pediatric Health
- Developmental Psychology
- Public Health
Background:
- Maternal smoking during pregnancy is a known risk factor for behavioral disorders in children.
- Limited prospective research exists on the specific effects of prenatal smoking on preschooler cognitive development.
Purpose of the Study:
- To investigate the association between maternal smoking during pregnancy and cognitive abilities in preschoolers.
- To quantify the impact of smoking on various cognitive domains in early childhood.
Main Methods:
- A birth cohort of 420 children was established, with data collected via maternal questionnaires and cognitive assessments (McCarthy Scales of Children's Abilities) at age 4.
- Multivariable regression analyses adjusted for numerous confounding factors including socioeconomic status, parental education, and child's environment.
- Maternal smoking habits were assessed prospectively throughout pregnancy and childhood.
Main Results:
- Maternal smoking during pregnancy was significantly associated with lower global cognitive scores in children.
- Specific cognitive sub-areas affected include verbal, quantitative, executive function, and working memory.
- A dose-response relationship was observed, with higher daily cigarette consumption correlating with greater cognitive deficits.
Conclusions:
- Maternal smoking during pregnancy is associated with impaired cognitive development in children by age 4.
- These findings underscore the importance of smoking cessation interventions for pregnant women to support optimal child cognitive outcomes.
Background:
Active maternal smoking during pregnancy has been associated with a higher risk of behavioural disorders in children, but a few cohort studies measuring smoking data prospectively have studied its specific effects on the cognitive abilities of pre-schoolers.
Method:
A birth cohort was set up in Menorca Island in 1997 within the Asthma Multicenter Infants Cohort Study. A total of 420 (87% of those eligible) children had complete data for final analyses at age 4 years. Interviewer-administered questionnaires were completed by mothers during the third trimester of pregnancy and then every year up to age 4 years of their child. A standardized version of the McCarthy Scales of Children's Abilities (MCSA) was used to evaluate the child's motor and cognitive capabilities. Multivariable regressions were used with MCSA's assessed outcomes adjusting for: home location, maternal alcohol consumption, mother's social class and level of education during pregnancy, parity, marital status, father's education level, child's gender, birth weight and height, breastfeeding duration, passive smoking, school season, age during test administration and evaluator (psychologist).
Results:
A high global consistency in maternal smoking habits was found (total agreement = 88.7%). Maternal social class and education level were inversely associated with maternal smoking behaviour. Maternal smoking during pregnancy (in cig./day) was associated with a decrease (in points) of children's global cognitive score [beta = -0.60, (95% CI: -1.10; -0.09)]; as well as global cognitive sub-areas like verbal score [beta = -0.59, (95% CI: -1.11; -0.07)]; quantitative score [beta = -0.57, (95% CI: -1.08; -0.06)]; executive function score [beta = -0.71, (95% CI: -1.23; -0.20)]; and working memory score [beta = -0.46, (95% CI: -0.92; -0.01)].
Conclusion:
Our findings suggest an association with maternal smoking during pregnancy and lowered cognitive development in children at age 4 years.
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