[A method for modelling obstructive and nonobstructive hydroureteronephrosis (experimental research)]

An experimental model of the upper urinary tract obstruction by means of cryosurgical liquid nitrogen destruction of an ureteral part has been created. The rabbit models provided obstructive ureterohydronephrosis in 100% of the animals, 56% of the dogs developed ureteral stricture in line with urodynamic alterations, the rest 44% had symptoms of nonobstructive ureterohydronephrosis as shown by excretory urography and dynamic nephroscintigraphy. One--three months after the destruction in dogs there were shifts in the intra-ureteral pressure and bioelectric activity, contractility of the fragments. The histological examination of the sections revealed necrosis at the destroyed site in the early postexposure period (2 weeks) followed by sclerosis and circulatory disturbances later on (3 months). The technique is simple, feasible in all laboratory animal species, highly reproducible.