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[A method for modelling obstructive and nonobstructive hydroureteronephrosis (experimental research)].

V I Kirpatovskiĭ, I S Mudraia, Iu V Kudriavtsev

    Urologiia I Nefrologiia
    |September 1, 1991
    PubMed
    Summary
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    Cryosurgery effectively models upper urinary tract obstruction in animals. This technique creates ureteral damage, leading to conditions like ureterohydronephrosis and stricture, useful for research.

    Area of Science:

    • Urology
    • Experimental Surgery
    • Nephrology

    Background:

    • Upper urinary tract obstruction is a significant clinical issue.
    • Developing reliable animal models is crucial for studying obstructive uropathy.
    • Cryosurgery offers a potential method for inducing controlled ureteral damage.

    Purpose of the Study:

    • To create and validate an experimental model of upper urinary tract obstruction.
    • To assess the efficacy and reproducibility of cryosurgical liquid nitrogen destruction of the ureter.
    • To investigate the resulting urodynamic and histological changes.

    Main Methods:

    • Cryosurgical liquid nitrogen destruction of a ureteral segment in rabbits and dogs.
    • Evaluation of ureterohydronephrosis using excretory urography and dynamic nephroscintigraphy.

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  • Urodynamic assessment, including intra-ureteral pressure and bioelectric activity measurements.
  • Histological examination of ureteral tissues at various time points post-procedure.

    • Main Results:

    • 100% of rabbit models developed obstructive ureterohydronephrosis.
    • 56% of dog models showed ureteral stricture with urodynamic alterations.
    • 44% of dogs exhibited nonobstructive ureterohydronephrosis.
    • Histology revealed early necrosis followed by later sclerosis and circulatory disturbances.

    Conclusions:

    • Cryosurgery is a simple, feasible, and reproducible method for creating experimental upper urinary tract obstruction.
    • The model effectively induces ureteral damage, stricture, and subsequent functional changes.
    • This cryosurgical model is suitable for studying the pathophysiology and treatment of obstructive uropathy.