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Updated: Jul 9, 2026
04:48
Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
Acute ventricular and aortic thrombosis post chemotherapy.
J F Morlese1, T Jeswani, I Beal
1Royal Free Hospital, Pond Street, London, UK. james.bell@royalfree.nhs.uk
The British Journal of Radiology
|June 7, 2007
Summary
A rare case of arterial thrombosis occurred in a 42-year-old male after cisplatin chemotherapy for esophageal cancer. This suggests chemotherapy and cancer may induce severe arterial and cardiac thrombosis.
Area of Science:
- Oncology
- Cardiology
- Vascular Medicine
Background:
- Esophageal adenocarcinoma is a significant malignancy.
- Cisplatin-based chemotherapy is a standard treatment for esophageal cancer.
- Arterial thrombosis is a serious complication that requires prompt diagnosis and management.
Observation:
- A 42-year-old male presented with acute bilateral lower limb pain and weakness.
- The patient had recently received his first cycle of cisplatin-based chemotherapy for esophageal adenocarcinoma.
- Imaging revealed extensive abdominal aortic thrombus and left ventricular thrombus.
Findings:
- The patient experienced spontaneous arterial thrombosis, a rare event.
- The thrombosis occurred in a native, non-aneurysmal aorta.
- The findings suggest a link between chemotherapy, malignancy, and thrombosis.
Implications:
- This case highlights a potential severe adverse effect of cisplatin chemotherapy.
- It underscores the importance of considering hypercoagulable states in patients with cancer and thrombosis.
- Further research is needed to elucidate the mechanisms and risk factors for chemotherapy-induced thrombosis.
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