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Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays
Published on: April 23, 2012
Fusaristatins A and B, two new cyclic lipopeptides from an endophytic Fusarium sp
Yoshihito Shiono1, Mio Tsuchinari, Keiko Shimanuki
1Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Japan. yshiono@tds1.tr.yamagata-u.ac.jp
Abstract:
Two new cyclic lipopeptides, fusaristatins A (1) and B (2) were isolated from rice cultures of a Fusarium sp. YG-45 in the course of a screening of endophytic fungi. Their structures of 1 and 2 were determined by spectroscopic methods. 2 showed a moderate inhibitory effect on topoisomerases I (IC50: 73 microM) and II (IC50: 98 microM) without cleavable complexes. Furthermore, 1 and 2 showed the growth-inhibitory activity toward lung cancer cells LU 65 with IC50 values of 23 and 7 microM, respectively.
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