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The first hydroxylated archazolid from the myxobacterium Cystobacter violaceus: isolation, structural elucidation and
Dirk Menche1, Jorma Hassfeld, Heinrich Steinmetz
1Helmholtz-Zentrum für Infektionsforschung GmbH, Medicinal Chemistry and Chemical Biology, Braunschweig, Germany. dirk.menche@helmoltz-hzi.de
Abstract:
The novel macrocyclic polyketide, 10-hydroxymethyl-archazolid-7-O-beta-D-glucopyranoside (archazolid D), was obtained from the myxobacterium Cystobacter violaceus. The structure of this first hydroxylated archazolid was determined by spectroscopic analysis, in particular by HMBC, HMQC, and ROESY NMR investigations, and by degradation. This novel metabolite was evaluated for growth inhibition of murine connective tissue cells and V-ATPase inhibition in comparison to other known archazolids.
