[The biochemical characteristics of the sperm in patients with varicocele]

Biochemical evaluation of ejaculates from males suffering from varicocele provided evidence on reduced fertility of their gametes mainly due to these cells hypoactivity consequent to insufficient generation of energy supplied during fructose oxidation. Lowered intensity of fructose oxidation in gamete mitochondria led to lactate accumulation in line with ultrastructural derangement of the flagellum and mitochondria with inhibition of dehydrogenases activity. Morphological abnormalities of the gametes are attributed to impaired gametogenesis in reproductive system of men with varicocele.