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Updated: Jul 14, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
Preaxial polydactyly in neurofibromatosis 1
Marwan Shinawi1, Millan S Patel
1Department of Molecular and Human Genetics, Baylor College of Medicine Texas Children's Hospital, Houston, Texas, USA.
Abstract:
Although skeletal manifestations are a cardinal feature of neurofibromatosis 1, they are largely confined to the axial skeleton and tibiae. In contrast, congenital malformations of the extremities are less common in patients with neurofibromatosis 1, occurring in fewer than 10%. We describe a boy with bilateral, symmetrical polysyndactyly (preaxial polydactyly type IV) and neurofibromatosis 1. This report discusses peripheral skeletal malformations in neurofibromatosis 1 and their possible etiology.
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