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Depression after infection with West Nile virus
Kristy O Murray1, Melissa Resnick, Vicki Miller
1University of Texas Health Science Center, Houston, Texas 77030, USA. kristy.o.murray@uth.tmc.edu
Emerging Infectious Diseases
|June 8, 2007
Summary
West Nile virus (WNV) infection can lead to new-onset depression in a significant portion of patients. Many experience mild-to-severe depressive symptoms, highlighting the need for clinical awareness.
Area of Science:
- Neuroscience
- Infectious Diseases
- Psychiatry
Background:
- West Nile virus (WNV) is a mosquito-borne illness with known neurological implications.
- Previous reports suggest a link between WNV infection and subsequent depression.
Purpose of the Study:
- To quantify the incidence of new-onset depression following West Nile virus infection.
- To assess the severity of depression in affected patients.
Main Methods:
- A cohort of patients with West Nile virus infection was assessed for depression.
- The Center for Epidemiologic Studies Depression (CES-D) scale was used to measure depressive symptoms.
Main Results:
- 31% of patients reported new-onset depression after WNV infection.
- Among those with new-onset depression, 75% exhibited CES-D scores indicating mild-to-severe depression.
Conclusions:
- West Nile virus infection is associated with a substantial risk of developing new-onset depression.
- Physicians must recognize the potential for neuropsychiatric complications, including depression, in WNV patients.
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