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Morphological and functional changes of cardiovascular system in postmenopausal women
N Alessandri1, M G Piccioni, V Isabelli
1Dipartimento del Cuore e Grossi Vasi A. Reale U.O.S. Cardiology Polo Pontino, University of Rome La Sapienza, Rome, Italy. nicola.alessandri@uniroma1.it
Insights
Menopause significantly alters cardiovascular risk factors in women. This study compared physiological and iatrogenic menopause, revealing distinct risk profiles and informing prevention strategies for postmenopausal women.
Area of Science:
- Cardiovascular Health
- Menopause Research
- Women's Health
Background:
- Cardiovascular event incidence is lower in reproductive-age women than men, but this shifts significantly at menopause.
- Postmenopausal women face increased exposure to risk factors, differing between physiological and surgical menopause, with or without hormone replacement therapy.
Purpose of the Study:
- To investigate and compare cardiovascular risk factors in postmenopausal women experiencing physiological versus iatrogenic menopause.
- To analyze the impact of substitutive hormonal treatment in women with iatrogenic menopause.
Main Methods:
- A study involving 743 postmenopausal women (545 physiological, 198 iatrogenic menopause) conducted in Rome and Latina.
- Comparative analysis of risk factors including blood pressure, hypertension, hypercholesterolemia, diabetes mellitus, obesity, and smoking.
Main Results:
- Significant differences observed in average blood pressure and the incidence of hypertension, hypercholesterolemia, diabetes mellitus, obesity, and smoking between physiological and iatrogenic postmenopausal groups.
- Risk factor trends varied within the iatrogenic group based on the use of substitutive hormonal treatment.
Conclusions:
- Understanding lifestyle and risk factors in postmenopausal women is crucial for effective health management.
- This research provides an updated prevalence of health conditions, enabling targeted primary and secondary prevention actions for postmenopausal women.
Background:
The incidence of cardiovascular events in reproductive age women is 3 times lower than in men, whereas this ratio noticeably changes on menopausal beginning. Postmenopausal women are more exposed to the effects of risk factors, which are present in a noticeably different entity in physiological or surgical menopause; and in the latter whether on substitutive hormonal treatment or not.
Methods:
This study, carried out in Rome and Latina, has involved 743 postmenopausal women, of whom 545 with physiological menopause and 198 with iatrogenic menopause.
Results:
The average blood pressure value as well as the incidence of hypertension, hypercholesterolemia, diabetes mellitus, obesity and smoking have a significantly different trend in physiological versus iatrogenic postmenopausal women; and in the latter whether on substitutive hormonal treatment or not.
Conclusions:
Studying life-style and evaluating risk factors in postmenopausal women, and giving an up-to-date view about the prevalence oh health conditions at risk, will allow us to promote both primary and secondary prevention actions.
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