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Updated: Jul 14, 2026
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Morphological and functional changes of cardiovascular system in postmenopausal women
N Alessandri1, M G Piccioni, V Isabelli
1Dipartimento del Cuore e Grossi Vasi A. Reale U.O.S. Cardiology Polo Pontino, University of Rome La Sapienza, Rome, Italy. nicola.alessandri@uniroma1.it
Background:
The incidence of cardiovascular events in reproductive age women is 3 times lower than in men, whereas this ratio noticeably changes on menopausal beginning. Postmenopausal women are more exposed to the effects of risk factors, which are present in a noticeably different entity in physiological or surgical menopause; and in the latter whether on substitutive hormonal treatment or not.
Methods:
This study, carried out in Rome and Latina, has involved 743 postmenopausal women, of whom 545 with physiological menopause and 198 with iatrogenic menopause.
Results:
The average blood pressure value as well as the incidence of hypertension, hypercholesterolemia, diabetes mellitus, obesity and smoking have a significantly different trend in physiological versus iatrogenic postmenopausal women; and in the latter whether on substitutive hormonal treatment or not.
Conclusions:
Studying life-style and evaluating risk factors in postmenopausal women, and giving an up-to-date view about the prevalence oh health conditions at risk, will allow us to promote both primary and secondary prevention actions.
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