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Pore-scale Imaging and Characterization of Hydrocarbon Reservoir Rock Wettability at Subsurface Conditions Using X-ray Microtomography
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[Study on alpha-asarone reservoir-type patch].

Zheng Wu1, Jian-Qing Gao, Hai-Liang Chen

  • 1Institute of pharmaceutics, Zhe jiang University, Hangzhou 310058, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|June 8, 2007
PubMed
Summary

This study developed an alpha-asarone reservoir patch for enhanced transdermal delivery. A combination of ethanol and Isopropyl Myristate (IPM) significantly improved drug permeation, meeting clinical needs.

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Area of Science:

  • Pharmacology
  • Materials Science
  • Drug Delivery

Background:

  • Alpha-asarone is a compound with potential therapeutic applications.
  • Transdermal drug delivery offers advantages over conventional routes.
  • Optimizing drug release and absorption is crucial for efficacy.

Purpose of the Study:

  • To formulate an alpha-asarone reservoir patch.
  • To evaluate in vitro release and transdermal absorption characteristics.
  • To identify effective permeation enhancers for alpha-asarone.

Main Methods:

  • Preparation of alpha-asarone reservoir patch using hydroxypropyl methylcellulose (HPMC) and ethylene vinyl acetate (EVA) membrane.
  • Utilized Franz diffusion cells for in vitro permeation studies.
  • High-performance liquid chromatography (HPLC) for quantifying alpha-asarone.

Main Results:

  • The alpha-asarone patch exhibited zero-order release kinetics in vitro.
  • A combination of 30% ethanol and 1% Isopropyl Myristate (IPM) demonstrated optimal permeation enhancement.
  • The maximal permeation rate achieved was (20.67 +/- 1.33) microg x cm(-2) h(-1).

Conclusions:

  • Ethanol and IPM act as effective permeation enhancers for alpha-asarone.
  • The developed patch formulation shows potential for clinical application.
  • Further investigation into skin irritation and bioavailability is warranted.