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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...

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Related Experiment Video

Updated: Jul 14, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

[Atopic dermatitis and food allergies].

A H Benhamou1, P A Eigenmann

  • 1Département de pédiatrie, HUG, 1211 Genève 14. Avigael.Benhamou@hcuge.ch

Revue Medicale Suisse
|June 8, 2007
PubMed
Summary

Atopic dermatitis affects 13% of Swiss children, often linked to food allergies like eggs, milk, and peanuts. Allergy testing can identify triggers, potentially improving eczema symptoms through allergen avoidance.

Area of Science:

  • Dermatology
  • Allergology
  • Pediatrics

Context:

  • Atopic dermatitis (eczema) impacts 13% of children in Switzerland.
  • Characterized by skin barrier defects, increasing water loss and allergen entry.
  • Moderate-to-severe cases show a 34% prevalence of food allergies.

Purpose:

  • To explore the connection between atopic dermatitis and allergies in children.
  • To highlight the role of food and respiratory allergens in eczema exacerbation.
  • To emphasize the diagnostic value of allergy testing for improved management.

Summary:

  • Food allergies (eggs, milk, peanuts) are common in children with moderate-to-severe atopic dermatitis, causing immediate or delayed reactions.
  • Respiratory allergens can trigger eczema flares in older children and adults.

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Related Experiment Videos

Last Updated: Jul 14, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

  • Allergy testing, including skin prick tests and food challenges, identifies atopic individuals at risk for rhinitis and asthma.
  • Impact:

    • Identifying specific allergies allows for targeted allergen avoidance strategies.
    • Potential improvement of skin symptoms and overall quality of life for patients.
    • Informs clinical practice regarding comprehensive allergy assessment in atopic dermatitis management.