Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Toxic epidermal necrolysis].

P L Bigliardi1, W Raffoul, M M Berger

  • 1Service de dermatologie et vénéréologie, Centre des brûléś, CHUV, 1011 Lausanne.

Revue Medicale Suisse
|June 8, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition.

Clinical nutrition (Edinburgh, Scotland)·2025
Same author

Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition.

JPEN. Journal of parenteral and enteral nutrition·2025
Same author

Indications, outcomes, and complications of neoumbilical reconstruction: A systematic review.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2023
Same author

Foodborne botulism, a forgotten yet life-threatening disease: a case report.

European review for medical and pharmacological sciences·2022
Same author

A rare complication of radiofrequency treatment for cellulite of the lower leg.

JPRAS open·2022
Same author

Improving nutritional therapy of persistent critically ill patients by organisational measures: A before and after study.

Clinical nutrition ESPEN·2021
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

[Erythema multiforme : target deciphering].

Revue medicale suisse·2026
See all related articles

Toxic epidermal necrolysis (TEN) is a severe drug reaction causing skin detachment and mucosal erosions. Early drug withdrawal and specialized burn unit care significantly reduce TEN mortality.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Context:

  • Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous reaction.
  • Often triggered by medications, it involves keratinocyte apoptosis and widespread epidermal detachment.
  • Patients exhibit severe illness, resembling burn victims, with potential organ failure.

Purpose:

  • To highlight the complexities in managing patients with toxic epidermal necrolysis.
  • To emphasize the critical role of a multidisciplinary approach in TEN treatment.
  • To discuss the ongoing debate regarding optimal medical interventions for TEN.

Summary:

  • TEN presents with epidermal separation and mucosal erosions, frequently drug-induced.
  • Management involves immediate drug cessation and intensive care, akin to burn treatment.

Related Experiment Videos

  • Despite advances, effective treatments to halt keratinocyte apoptosis remain under investigation.

    • Impact:

    • Prompt intervention and specialized care can decrease the high mortality associated with TEN.
    • A collaborative, multidisciplinary strategy is crucial for improving patient outcomes in TEN.
    • This case report underscores the need for further research into TEN pathogenesis and treatment.