[Kahler's disease. Multiple myeloma].

Area of Science:

• Hematology
• Oncology

Background:

• Multiple myeloma (Kahler's disease) is a bone marrow cancer characterized by uncontrolled plasma cell proliferation.
• Clinical manifestations include anemia, bone pain, fractures, and increased infection risk, potentially progressing to renal failure.

Observation:

• Current chemotherapy achieves good response in 50-70% of multiple myeloma patients, with complete remission in a minority.
• Radiotherapy and bisphosphonates are common adjuncts; bisphosphonates inhibit osteolysis but are linked to jaw osteonecrosis.

Findings:

• A recent association has been identified between bisphosphonate use and the development of osteonecrosis of the jaw (ONJ).

Implications:

• Consultation with a patient's hematologist is crucial before initiating invasive oral treatments to mitigate the risk of ONJ.
• This highlights the importance of multidisciplinary care in managing multiple myeloma and its treatment complications.