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Updated: Jul 14, 2026
14:48
Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis
Published on: May 8, 2021
[Population screening for urinary protein loss: a sensible action]
P E de Jong1, R T Gansevoort, J F M Wetzels
1Universitair Medisch Centrum Groningen, afd. Nefrologie, Postbus 30.001, 9700 RB Groningen. p.e.de.jong@int.umcg.nl
Nederlands Tijdschrift Voor Geneeskunde
|June 8, 2007
Summary
Urinary dipstick screening can detect hidden kidney disease, with positive results indicating potential macroalbuminuria or microalbuminuria. Early detection through screening for urinary protein loss is cost-effective for renal and cardiac protection.
Area of Science:
- Nephrology
- Public Health
- Diagnostic Medicine
Context:
- The Dutch Kidney Foundation initiated a large-scale screening program using urinary dipsticks in 2006.
- A significant portion of the adult population may have undiagnosed chronic kidney disease (CKD).
- Screening for proteinuria and albuminuria can identify individuals with early-stage renal damage.
Purpose:
- To assess the prevalence of undiagnosed renal disease through widespread urinary protein loss screening.
- To evaluate the effectiveness and cost-effectiveness of population-based screening for kidney disease.
- To promote early diagnosis and intervention for conditions leading to end-stage renal disease.
Summary:
- Over one million people participated in the Dutch screening initiative within two weeks.
- Japanese studies suggest 5% of the general population may have positive dipstick tests, with 1-3% exhibiting significant albuminuria.
- Positive dipstick tests can indicate manifest glomerular damage (macroalbuminuria) or underlying diabetes/hypertension (microalbuminuria).
Impact:
- Early detection of proteinuria/albuminuria enables timely treatment with renin-angiotensin-aldosterone system (RAAS) blockade.
- RAAS blockade improves renal and cardiac survival in patients with known renal disease and proteinuria.
- Screening for urinary protein loss is considered a cost-effective strategy for preventing end-stage renal disease and cardiovascular events.
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