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Updated: Jul 14, 2026

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation
Published on: April 24, 2020
Plasma/serum proteomics: pre-analytical issues
Stefano Barelli1, David Crettaz, Lynne Thadikkaran
1Service Régional Vaudois de Transfusion Sanguine, Lausanne, Switzerland. stefano.barelli@srtsvd.ch
Abstract:
High-throughput proteomics technologies tend to provide highly sensitive information about living tissues and biological fluids. Analytes are characterized by intrinsic and extrinsic properties, the latter depending on each phase of their preparation, sometimes adding artifacts with crucial repercussions in result reliability and interpretation. This review aims to address some issues that can be encountered when handling plasma and serum in experimental and clinical proteomic settings.