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Updated: Jul 14, 2026
08:49
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
Published on: May 28, 2021
Artificial reduction in transepidermal water loss improves skin barrier function
I Buraczewska1, U Broström, M Lodén
1ACO HUD NORDIC AB, Research and Development, Box 622, SE-194 26 Upplands Väsby, Sweden.
The British Journal of Dermatology
|June 8, 2007
Summary
Prolonged daily occlusion with a silicone membrane significantly improves skin barrier function. Shorter daily application periods did not yield significant results, suggesting occlusion duration is key for barrier repair.
Area of Science:
- Dermatology
- Skin Barrier Science
- Cosmetic Science
Background:
- Abnormal transepidermal water loss (TEWL) is linked to skin barrier dysfunction.
- Moisturizers can impact skin barrier function, but the role of occlusion is unclear.
Purpose of the Study:
- To assess long-term effects of a semipermeable membrane on skin barrier function.
- To compare the occlusive properties of two different creams.
Main Methods:
- Randomized, controlled, evaluator-blind study design.
- Transepidermal water loss (TEWL) measurements.
- Skin susceptibility testing using sodium lauryl sulphate.
Main Results:
- Daily 23-hour silicone membrane application for 3 weeks enhanced skin barrier function.
- No significant barrier function changes were observed with 8-hour daily application.
- Occlusive properties alone do not fully explain cream efficacy on skin barrier function.
Conclusions:
- Extended occlusion is crucial for improving skin barrier function.
- Cream occlusivity is not the sole determinant of their impact on skin barrier health.
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