Related Experiment Video
Updated: Jul 14, 2026

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
Published on: March 10, 2017
MRSA transmission between cows and humans
Eva Juhász-Kaszanyitzky1, Szilárd Jánosi, Pál Somogyi
1Central Veterinary Institute, Budapest, Hungary. juhasznee@oai.hu
Abstract:
We isolated methicillin-resistant Staphylococcus aureus (MRSA) from cows with subclinical mastitis and from a person who worked with these animals. The bovine and human strains were indistinguishable by phenotyping and genotyping methods and were of a low frequency spa type. To our knowledge, this finding indicates the first documented case of direct transmission of MRSA between cows and humans.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) was found in cows and a farm worker. The identical strains suggest the first documented direct transmission of MRSA between cattle and humans.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Microbiology
Background:
- Subclinical mastitis is a significant concern in dairy herds.
- Methicillin-resistant Staphylococcus aureus (MRSA) poses a zoonotic risk.
- Understanding animal-to-human pathogen transmission is crucial for public health.
Purpose of the Study:
- To investigate the potential link between bovine and human MRSA strains.
- To document the first instance of direct MRSA transmission between cattle and humans.
Main Methods:
- Isolation of MRSA from subclinically infected cows and a human handler.
- Phenotypic characterization of bacterial isolates.
- Genotypic analysis, including spa typing, to compare strains.
Main Results:
- MRSA was successfully isolated from both bovine and human sources.
- Bovine and human MRSA strains were indistinguishable using applied methods.
- The identified MRSA strain belonged to a low-frequency spa type.
Conclusions:
- The findings suggest direct transmission of MRSA from cattle to humans.
- This represents a novel documented case of cow-to-human MRSA transfer.
- Highlights the importance of surveillance for zoonotic pathogens in livestock settings.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Transmission of Pathogens
Mechanism of Antibiotic Resistance in MRSA
Mismatch Repair
Reservoir of Infection
Inhalation Anthrax

