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Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions
Published on: September 10, 2021
Human bocavirus, a respiratory and enteric virus
Diego Vicente1, Gustavo Cilla, Milagrosa Montes
1Hospital Donostia, San Sebastián, Spain.
Emerging Infectious Diseases
|June 8, 2007
Summary
Human bocavirus (HBoV) was found in the feces of Spanish children with gastroenteritis. This finding is significant as it is the first report of HBoV fecal shedding, raising concerns about its transmission routes.
Area of Science:
- Virology
- Pediatrics
- Infectious Diseases
Background:
- Human bocavirus (HBoV) is a known cause of respiratory illness in children.
- The transmission routes and clinical significance of HBoV, particularly in gastroenteritis, are not fully understood.
Purpose of the Study:
- To investigate the prevalence of human bocavirus (HBoV) in children with gastroenteritis in Spain.
- To determine if HBoV is shed in the feces of affected children.
Main Methods:
- A cross-sectional study was conducted involving 527 children diagnosed with gastroenteritis.
- Fecal samples were analyzed for the presence of HBoV using molecular detection methods.
Main Results:
- Human bocavirus (HBoV) was detected in 9.1% (48/527) of children with gastroenteritis.
- The detection frequency was similar to that observed in children with respiratory illness (7.7%, 40/520).
- This study provides the first evidence of HBoV detection in human feces.
Conclusions:
- Human bocavirus (HBoV) is present in the fecal samples of children with gastroenteritis in Spain.
- The fecal shedding of HBoV suggests potential fecal-oral transmission routes, warranting further investigation.
- These findings expand the understanding of HBoV's clinical manifestations and transmission dynamics.
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