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[Correlation of CD40 gene polymorphisms with acute coronary syndrome, hypertension and diabetes]

Yan Li1, Cai-Xia Tian, Ming Wang

  • 1Department of Clinical Laboratory Science, Renmin Hospital of Wuhan University, Wuhan 430060, China. yanlitf@yahoo.com.cn

Zhonghua Yi Xue Za Zhi
|June 8, 2007
PubMed

Insights

The CD40-1C/T gene variant increases the risk of acute coronary syndrome (ACS) in Chinese individuals. This risk is amplified when combined with hypertension or diabetes.

Area of Science:

  • Genetics and Cardiovascular Disease
  • Molecular Biology
  • Population Genetics

Background:

  • The CD40 gene plays a role in immune responses and inflammation, which are implicated in the pathogenesis of atherosclerosis.
  • Genetic variations in the CD40 gene may influence an individual's susceptibility to cardiovascular diseases.

Purpose of the Study:

  • To examine the association between CD40 gene polymorphisms (CD40-E1SNP -1C/T and CD40-E4SNP) and the risk of acute coronary syndrome (ACS).
  • To investigate potential gene-environment interactions between CD40 polymorphisms and hypertension or diabetes in the Chinese Han population.

Main Methods:

  • Genotyping of CD40-E1SNP (-1C/T) and CD40-E4SNP using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing.
  • Analysis of allele and genotype frequencies in 160 ACS patients and 92 controls.
  • Multivariate logistic regression models to assess gene-environment interactions with hypertension and diabetes.

Main Results:

  • The CD40-1C allele frequency was significantly higher in ACS patients (0.606) compared to controls (0.489) (P < 0.01).
  • The C allele was associated with an increased risk of ACS (OR = 1.608, P = 0.011).
  • Significant gene-environment interactions were observed: C allele carriers with hypertension had an OR of 5.71 (P < 0.05), and those with diabetes had an OR of 2.35 (P < 0.01).
  • CD40-E4SNP expression was not detected in the study population.

Conclusions:

  • CD40-1C/T polymorphism is a risk factor for ACS in the Chinese population.
  • The presence of the -1C allele confers a higher risk of ACS, particularly when co-occurring with hypertension or diabetes.
  • The CD40-E4SNP may not be present or relevant in the Chinese population studied.
Abstract

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