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[Relationship between iceA1, iceA2 and babA2 genes of Hp in Xi'an and gastroduodenal diseases]
Kun Zhuang1, Jun Zhang, Ling-xia Zhang
1Department of Gastroenterology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
Aim:
To investigate the distribution of iceA1, iceA2 and babA2 genes of helicobacter pylori (Hp) in Xi'an and analyse the relationship between these genes and gastroduodenal diseases.
Methods:
88 Hp strains were isolated from the patients with different gastric duodenal diseases. After genomic DNA was extracted, iceA1, iceA2 and babA2 genotypes of Hp were determined by polymerase chain reaction (PCR). The results were analyzed statistically by chi(2) test.
Results:
88 Hp strains were detected from 163 samples and the detection rate was 54%. The positive rate of iceA1, iceA2 and babA2 of the 88 Hp strains was 76.1%, 21.6% and 25%, respectively. These genotypes showed no statistical difference in the distribution of different gastric duodenal diseases (P>0.05).
Conclusion:
iceA1 of Hp ispredominated in Xi'an area. These genotypes have no correlation with the clinical outcome of Hp infection.
