A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish
Roser Urreizti1, Carla Asteggiano, Maria Antonia Vilaseca
1Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, CIBERER, IBUB, Av Diagonal, 645, E-08028, Barcelona, Spain.
Objectives:
The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD).
Design And Methods:
We examined 8 polymorphisms in the cystathionine beta-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann-Whitney U test.
Results:
The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12-2.77), while a CBS haplotype [c.699C-c.844wt-c.1080C] was found over-represented in CAD [OR of 2.16 (1.29-3.63)].
Conclusions:
Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies.
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